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Basic Principles and Clinical Applications of CRISPR-Based Genome Editing

1 Jan 2022

Abstract excerpt

Advances in sequencing technologies have facilitated the discovery of previously unknown genetic variants in both inherited and acquired disorders, and tools to correct these pathogenic variants are rapidly evolving. Since the first introduction of CRISPR-Cas9 in 2012, the field of CRISPR-based genome editing has progressed immensely, giving hope to many patients suffering from genetic disorders that lack...

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PMID: 35083895
DOI: 10.3349/ymj.2022.63.2.105

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