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Article

Induction of Paraquat-Mediated Parkinsonian Phenotype in Zebrafish.

Current protocols - 1 Feb 2024

Harini V S, Marimuthu Raghunath, Tantry M S Ananthakrishna, Santhakumar Kirankumar

Abstract excerpt

Paraquat (PQ) is a well-known neurotoxin closely associated with neurodegenerative Parkinson's disease (PD). Zebrafish are utilized as a model for PD research because of their well-defined neuropathology and locomotor behavior. Here, we highlight protocols for inducing PD using PQ and analyzing locomotor activity in adult zebrafish. Basic Protocol 1 details the treatment of adult male zebrafish with 60 mg/kg PQ...

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PMID: 38348973
DOI: 10.1002/cpz1.990

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