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Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data

19 Jun 2021

Abstract excerpt

BACKGROUND: Due to the molecular mechanism complexity and heterogeneity of gastric cancer (GC), mechanistically interpretable biomarkers were required for predicting prognosis and discovering therapeutic targets for GC patients. METHODS: Based on a total of 824 GC-specific fitness genes from the Project Score database, LASSOCox regression was performed in TCGA-STAD cohort to construct a GC Prognostic (GCP) model...

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PMID: 34157484
DOI: 10.1016/j.ebiom.2021.103436

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