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FAM120A deficiency improves resistance to cisplatin in gastric cancer by promoting ferroptosis

2 Apr 2024

Abstract excerpt

The occurrence of chemoresistance is an inescapable obstacle affecting the clinical efficacy of cisplatin in gastric cancer (GC). Exploring the regulatory mechanism of cisplatin resistance will help to provide potential effective targets for improving the prognosis of gastric cancer patients. Here, we find that FAM120A is upregulated in GC tissues and higher in cisplatin-resistant GC tissues, and its high...

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PMID: 38565940
DOI: 10.1038/s42003-024-06097-6

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