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Stop-Codon Readthrough in Therapeutic Protein Candidates Expressed from Mammalian Cells

9 Feb 2024

Abstract excerpt

Stop codon readthroughs were examined in 48 recombinant therapeutic protein candidates produced from multiple clones of Chinese hamster ovary cells, using peptide mapping with LC-MS/MS detection. We found that stop codon readthrough is a common phenomenon occurring in most of these candidates, with levels varying from below the detection limit of ∼0.001 % to ∼1 %. The readthrough propensity depends on the stop...

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PMID: 38342339
DOI: 10.1016/j.xphs.2024.02.006

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