Article
Polymorphisms in the Annexin gene family and the risk of osteonecrosis of the femoral head in the Korean population.
Bone - 1 Jul 2009
Kim Tae-Ho, Hong Jung Min, Shin Eun-Soon, Kim Hyun-Ju, Cho Yoon Shin, Lee Jong-Young, Lee Sang-Han, Park Eui Kyun, Kim Shin-Yoon
Abstract excerpt
OBJECTIVE: The pathogenesis of osteonecrosis of the femoral head (ONFH) probably reflects multiple etiologies. Recent studies have explored associations between genetic mutations and/or polymorphisms and ONFH. Annexins (ANXs) have been implicated in many physiological functions, including blood coagulation, inflammation, apoptosis, as well as Ca(2+) homeostasis in bone cells, all of which may be associated with...
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