Article
Various mutations in icaR, the repressor of the icaADBC locus, occur in mucoid Staphylococcus aureus isolates recovered from the airways of people with cystic fibrosis.
Microbes and infection - 1 Jan 2000
Schwartbeck Bianca, Rumpf Christine H, Hait Robert Jonathan, Janssen Timo, Deiwick Susanne, Schwierzeck Vera, Mellmann Alexander, Kahl Barbara C
Abstract excerpt
Staphylococcus aureus is one of the major pathogens isolated from the airways of people with cystic fibrosis (pwCF). Recently, we described a mucoid S. aureus phenotype from respiratory specimens of pwCF, which constitutively overproduced biofilm that consisted of polysaccharide intercellular adhesin (PIA) due to a 5bp-deletion (5bp-del) in the intergenic region of the intercellular adhesin (ica) locus. Since we...
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