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Article

Clinicopathological significance of angiopoietin-like protein 4 expression in oesophageal squamous cell carcinoma

21 Sept 2010

Abstract excerpt

BACKGROUND: Angiopoietin-like protein 4 (ANGPTL4) is involved in regulating glucose homeostasis, insulin sensitivity, angiogenesis and lipid metabolism, and also acts as an apoptosis survival factor for vascular endothelial cells. The protein is also known to be induced in hypoxic environments characteristic of cancer tissue. Recently, ANGPTL4 was shown in cancer cells to facilitate the transendothelial passage...

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PMID: 20861003
DOI: 10.1136/jcp.2010.078600

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