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Distinct intratumoral microbiome of young-onset and average-onset colorectal cancer

1 Feb 2024

Abstract excerpt

BACKGROUND: The unexplained rise of young-onset CRC (yoCRC, age <50 years) is of concern. Evidence suggests that microbial dysbiosis may be a contributing factor, but the tumor microbial profile of yoCRC in comparison to average-onset CRC (aoCRC, age >60) has not been fully investigated. METHODS: 16S rRNA amplicon sequencing was performed in tumor and paired adjacent non-malignant fresh frozen tissue specimens...

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PMID: 38306898
DOI: 10.1016/j.ebiom.2024.104980

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