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Multi-cohort analysis reveals colorectal cancer tumor location-associated fecal microbiota and their clinical impact

1 Apr 2025

Abstract excerpt

Microbial alterations in different tumor locations of colorectal cancer (CRC) remain unclear. Here, 1,375 fecal metagenomes from six in-house and published datasets were analyzed, including 128 right-sided CRC (rCRC), 168 left-sided CRC (lCRC), 250 rectal cancer (RC), and 829 controls. Firmicutes progressively increase from rCRC, lCRC, to RC, in contrast to the gradual decrease of Bacteroidetes. Tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40209677
DOI: 10.1016/j.chom.2025.03.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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