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Oncomicrobial Community Profiling Identifies Clinicomolecular and Prognostic Subtypes of Colorectal Cancer.

Gastroenterology - 1 Jul 2023

Mouradov Dmitri, Greenfield Paul, Li Shan, In Eun-Jung, Storey Claire, Sakthianandeswaren Anuratha, Georgeson Peter, Buchanan Daniel D, Ward Robyn L, Hawkins Nicholas J, Skinner Iain, Jones Ian T, Gibbs Peter, Ma Chenkai, Liew Yi Jin, Fung Kim Y C, Sieber Oliver M

Abstract excerpt

BACKGROUND & AIMS: Dysbiosis of gut microbiota is linked to the development of colorectal cancer (CRC). However, microbiota-based stratification of CRC tissue and how this relates to clinicomolecular characteristics and prognosis remains to be clarified. METHODS: Tumor and normal mucosa from 423 patients with stage I to IV CRC were profiled by bacterial 16S rRNA gene sequencing. Tumors were characterized for...

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PMID: 36933623
DOI: 10.1053/j.gastro.2023.03.205

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