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SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis

30 Jan 2024

Abstract excerpt

Pyroptosis, a pro-inflammatory programmed cell death, has been implicated in the pathogenesis of coronavirus disease 2019 and other viral diseases. Gasdermin family proteins (GSDMs), including GSDMD and GSDME, are key regulators of pyroptotic cell death. However, the mechanisms by which virus infection modulates pyroptosis remain unclear. Here, we employed a mCherry-GSDMD fluorescent reporter assay to screen for...

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PMID: 38289118
DOI: 10.1128/jvi.01909-23

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