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Copy number gain of FAM131B-AS2 promotes the progression of glioblastoma by mitigating replication stress

24 Jan 2024

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) is characterized by chromosome 7 copy number gains, notably 7q34, potentially contributing to therapeutic resistance, yet the underlying oncogenes have not been fully characterized. Pertinently, the significance of long noncoding RNAs (lncRNAs) in this context has gained attention, necessitating further exploration. METHODS: FAM131B-AS2 was quantified in GBM samples and cells using...

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PMID: 38285005
DOI: 10.1093/neuonc/noae014

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