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Core fucosylation regulates the ovarian response via FSH receptor during follicular development

26 Jan 2024

Abstract excerpt

Ovarian low response to follicle-stimulating hormone (FSH) causes infertility featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective ovarian response. N-glycosylation is essential for FSH receptor (FSHR). Core fucosylation catalyzed by fucosyltransferase 8 (FUT8) is the most common N-glycosylation. Core fucosylation level changes between individuals and plays important roles in multiple...

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PMID: 38280716
DOI: 10.1016/j.jare.2024.01.025

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