Article
Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people.
Science advances - 26 Jan 2024
Koyanagi Yuriko N, Nakatochi Masahiro, Namba Shinichi, Oze Isao, Charvat Hadrien, Narita Akira, Kawaguchi Takahisa, Ikezaki Hiroaki, Hishida Asahi, Hara Megumi, Takezaki Toshiro, Koyama Teruhide, Nakamura Yohko, Suzuki Sadao, Katsuura-Kamano Sakurako, Kuriki Kiyonori, Nakamura Yasuyuki, Takeuchi Kenji, Hozawa Atsushi, Kinoshita Kengo, Sutoh Yoichi, Tanno Kozo, Shimizu Atsushi, Ito Hidemi, Kasugai Yumiko, Kawakatsu Yukino, Taniyama Yukari, Tajika Masahiro, Shimizu Yasuhiro, Suzuki Etsuji, Hosono Yasuyuki, Imoto Issei, Tabara Yasuharu, Takahashi Meiko, Setoh Kazuya, Matsuda Koichi, Nakano Shiori, Goto Atsushi, Katagiri Ryoko, Yamaji Taiki, Sawada Norie, Tsugane Shoichiro, Wakai Kenji, Yamamoto Masayuki, Sasaki Makoto, Matsuda Fumihiko, Okada Yukinori, Iwasaki Motoki, Brennan Paul, Matsuo Keitaro
Abstract excerpt
An East Asian-specific variant on aldehyde dehydrogenase 2 (ALDH2 rs671, G>A) is the major genetic determinant of alcohol consumption. We performed an rs671 genotype-stratified genome-wide association study meta-analysis of alcohol consumption in 175,672 Japanese individuals to explore gene-gene interactions with rs671 behind drinking behavior. The analysis identified three genome-wide significant loci (GCKR,...