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Molecular profiling of human blastocysts reveals primitive endoderm defects among embryos of decreased implantation potential

26 Jan 2024

Abstract excerpt

Human embryo implantation is remarkably inefficient, and implantation failure remains among the greatest obstacles in treating infertility. Gene expression data from human embryos have accumulated rapidly in recent years; however, identification of the subset of genes that determine successful implantation remains a challenge. We leverage clinical morphologic grading-known for decades to correlate with...

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PMID: 38277271
DOI: 10.1016/j.celrep.2024.113701

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