Article
Natural reversion promotes LPS elongation in an attenuated Coxiella burnetii strain.
Nature communications - 24 Jan 2024
Long Carrie M, Beare Paul A, Cockrell Diane, Binette Picabo, Tesfamariam Mahelat, Richards Crystal, Anderson Matthew, McCormick-Ell Jessica, Brose Megan, Anderson Rebecca, Omsland Anders, Pearson Talima, Heinzen Robert A
Abstract excerpt
Lipopolysaccharide (LPS) phase variation is a critical aspect of virulence in many Gram-negative bacteria. It is of particular importance to Coxiella burnetii, the biothreat pathogen that causes Q fever, as in vitro propagation of this organism leads to LPS truncation, which is associated with an attenuated and exempted from select agent status (Nine Mile II, NMII). Here, we demonstrate that NMII was recovered...
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