Treatment of ZC4H2 Variant-Associated Spastic Paraplegia with Selective Dorsal Rhizotomy and Intensive Postoperative Rehabilitation: A Case Report.

doi:10.1620/tjem.2024.J004

Article

Treatment of ZC4H2 Variant-Associated Spastic Paraplegia with Selective Dorsal Rhizotomy and Intensive Postoperative Rehabilitation: A Case Report.

The Tohoku journal of experimental medicine - 24 Apr 2024

Inotani Toshiki, Horaguchi Akira, Morishita Yuko, Yoshida Ayuko, Otomo Misaki, Suzuki Makoto, Inui Takehiko, Okubo Yukimune, Komatsu Shigemasa, Mizuno Chika, Takahashi Yuko, Ochiai Tatsuhiro, Kinjo Takeshi, Asato Takashi, Takayama Jun, Tamiya Gen, Saijo Naoya, Kikuchi Atsuo, Haginoya Kazuhiro

Abstract excerpt

Selective dorsal rhizotomy (SDR) has been used to treat children with spastic cerebral palsy (CP), and its beneficial effect on quality of life and ambulation has been confirmed in long-term follow-up studies. However, the role of SDR in the treatment of spasticity in patients with hereditary spastic paraplegia (HSP) and related disorders is not well-established. Here, we report the first patient with the ZC4H2...

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