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Article

CAD204520 Targets NOTCH1 PEST Domain Mutations in Lymphoproliferative Disorders.

International journal of molecular sciences - 7 Jan 2024

Pagliaro Luca, Cerretani Elisa, Vento Federica, Montanaro Anna, Moron Dalla Tor Lucas, Simoncini Elisa, Giaimo Mariateresa, Gherli Andrea, Zamponi Raffaella, Tartaglione Isotta, Lorusso Bruno, Scita Matteo, Russo Filomena, Sammarelli Gabriella, Todaro Giannalisa, Silini Enrico Maria, Rigolin Gian Matteo, Quaini Federico, Cuneo Antonio, Roti Giovanni

Abstract excerpt

NOTCH1 PEST domain mutations are often seen in hematopoietic malignancies, including T-cell acute lymphoblastic leukemia (T-ALL), chronic lymphocytic leukemia (CLL), splenic marginal zone lymphoma (SMZL), mantle cell lymphoma (MCL), and diffuse large B-cell lymphoma (DLBCL). These mutations play a key role in the development and progression of lymphoproliferative tumors by increasing the Notch signaling and,...

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Share to Hematologic Neoplasms
Share to Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38255842
DOI: 10.3390/ijms25020766
PMCID: PMC10815907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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