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Article

Rare Deletions or Large Duplications Contribute to Genetic Variation in Patients with Severe Tinnitus and Meniere Disease.

Genes - 22 Dec 2023

Escalera-Balsera Alba, Parra-Perez Alberto M, Gallego-Martinez Alvaro, Frejo Lidia, Martin-Lagos Juan, Rivero de Jesus Victoria, Pérez-Vázquez Paz, Perez-Carpena Patricia, Lopez-Escamez Jose A

Abstract excerpt

Meniere disease (MD) is a debilitating disorder of the inner ear defined by sensorineural hearing loss (SNHL) associated with episodes of vertigo and tinnitus. Severe tinnitus, which occurs in around 1% of patients, is a multiallelic disorder associated with a burden of rare missense single nucleotide variants in synaptic genes. Rare structural variants (SVs) may also contribute to MD and severe tinnitus. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38254912
DOI: 10.3390/genes15010022
PMCID: PMC10815708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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