Article
Genome-wide association identifies novel ROP risk loci in a multiethnic cohort.
Communications biology - 17 Jan 2024
Li Xiaohui, Owen Leah A, Taylor Kent D, Ostmo Susan, Chen Yii-Der Ida, Coyner Aaron S, Sonmez Kemal, Hartnett M Elizabeth, Guo Xiuqing, Ipp Eli, Roll Kathryn, Genter Pauline, Chan R V Paul, DeAngelis Margaret M, Chiang Michael F, Campbell J Peter, Rotter Jerome I
Abstract excerpt
We conducted a genome-wide association study (GWAS) in a multiethnic cohort of 920 at-risk infants for retinopathy of prematurity (ROP), a major cause of childhood blindness, identifying 1 locus at genome-wide significance level (p < 5×10-8) and 9 with significance of p < 5×10-6 for ROP ≥ stage 3. The most significant locus, rs2058019, reached genome-wide significance within the full multiethnic cohort...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.