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Article

Onvansertib in Combination with FOLFIRI and Bevacizumab in Second-Line Treatment of KRAS-Mutant Metastatic Colorectal Cancer: A Phase Ib Clinical Study.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2024

Ahn Daniel H, Barzi Afsaneh, Ridinger Maya, Samuëlsz Errin, Subramanian Ramanand A, Wu Chu-Chiao, Croucher Peter J P, Smeal Tod, Kabbinavar Fairooz F, Lenz Heinz-Josef

Abstract excerpt

PURPOSE: Onvansertib is a highly specific inhibitor of polo-like kinase 1 (PLK1), with demonstrated safety in solid tumors. We evaluated, preclinically and clinically, the potential of onvansertib in combination with chemotherapy as a therapeutic option for KRAS-mutant colorectal cancer. PATIENTS AND METHODS: Preclinical activity of onvansertib was assessed (i) in vitro in KRAS wild-type and -mutant isogenic...

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Identifiers

PMID: 38231047
DOI: 10.1158/1078-0432.CCR-23-3053
PMCID: PMC11094418

Genes

KRAS
PLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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