Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer.

doi:10.1200/JCO.2009.27.6055

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Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Nov 2010

Peeters Marc, Price Timothy Jay, Cervantes Andrés, Sobrero Alberto F, Ducreux Michel, Hotko Yevhen, André Thierry, Chan Emily, Lordick Florian, Punt Cornelis J A, Strickland Andrew H, Wilson Gregory, Ciuleanu Tudor-Eliade, Roman Laslo, Van Cutsem Eric, Tzekova Valentina, Collins Simon, Oliner Kelly S, Rong Alan, Gansert Jennifer

Abstract excerpt

PURPOSE: Panitumumab is a fully human anti-epidermal growth factor receptor (EGFR) monoclonal antibody that improves progression-free survival (PFS) in chemotherapy-refractory metastatic colorectal cancer (mCRC). This trial evaluated the efficacy and safety of panitumumab plus fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone after failure of initial treatment for mCRC by tumor KRAS...

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Identifiers

PMID: 20921462
DOI: 10.1200/JCO.2009.27.6055

Genes

KRAS
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer.PMID 20921462Read ↗

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