Onvansertib in Combination With Chemotherapy and Bevacizumab in Second-Line Treatment of KRAS-Mutant Metastatic Colorectal Cancer: A Single-Arm, Phase II Trial.

doi:10.1200/JCO-24-01266

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Article

Onvansertib in Combination With Chemotherapy and Bevacizumab in Second-Line Treatment of KRAS-Mutant Metastatic Colorectal Cancer: A Single-Arm, Phase II Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 2025

Ahn Daniel H, Ridinger Maya, Cannon Timothy L, Mendelsohn Lawrence, Starr Jason S, Hubbard Joleen M, Kasi Anup, Barzi Afsaneh, Samuëlsz Errin, Karki Anju, Subramanian Ramanand A, Yemane Divora, Kim Roy, Wu Chu-Chiao, Croucher Peter J P, Smeal Tod, Kabbinavar Fairooz F, Lenz Heinz-Josef

Abstract excerpt

PURPOSE: This phase II study evaluated the efficacy and tolerability of onvansertib, a polo-like kinase 1 (PLK1) inhibitor, in combination with fluorouracil, leucovorin, and irinotecan (FOLFIRI) + bevacizumab for the second-line treatment of KRAS-mutant metastatic colorectal cancer (mCRC). PATIENTS AND METHODS: This multicenter, open-label, single-arm study enrolled patients with KRAS-mutated mCRC previously...

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PMID: 39475591
DOI: 10.1200/JCO-24-01266
PMCID: PMC11856007

Genes

KRAS
PLK1

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Onvansertib in Combination With Chemotherapy and Bevacizumab in Second-Line Treatment of KRAS-Mutant Metastatic Colorectal Cancer: A Single-Arm, Phase II Trial.PMID 39475591Read ↗

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