PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer.

doi:10.1200/JCO.2013.53.2473

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PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jul 2014

Schwartzberg Lee S, Rivera Fernando, Karthaus Meinolf, Fasola Gianpiero, Canon Jean-Luc, Hecht J Randolph, Yu Hua, Oliner Kelly S, Go William Y

Abstract excerpt

PURPOSE: To evaluate panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated wild-type (WT) KRAS exon 2 (codons 12 and 13) metastatic colorectal cancer (mCRC). A prespecified secondary objective was to assess treatment effects in an extended RAS analysis that included exons 2, 3, and 4 of KRAS and NRAS. PATIENTS AND METHODS:...

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PMID: 24687833
DOI: 10.1200/JCO.2013.53.2473

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