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A Universal Aptamer for Influenza A Viruses: Selection, Recognition, and Infection Inhibition

29 Dec 2023

Abstract excerpt

It is crucial to develop universal inhibitors for viral inhibition due to the rapid mutation of viruses. Herein, a universal aptamer inhibitor was developed that enabled a single DNA molecule to recognize several hemeagglutinin (HA) protein subtypes, inducing broad neutralization against influenza A viruses (IAVs). Through a multi-channel enrichment (MCE) strategy, a high-affinity aptamer named UHA-2 was...

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PMID: 38230279
DOI: 10.1021/acsptsci.3c00258

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