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Article

Characterizing the Molecular Mechanism of the Lethal C423D Mutation in FgMyoI: A Molecular Perspective.

Journal of agricultural and food chemistry - 24 Jan 2024

Bao Yiqiong, Jia Fangying, Li Mengrong, Xu Ran, Xie Yanjie, Zhang Feng, Guo Jingjing

Abstract excerpt

The lethal mutation C423D in Fusarium graminearum myosin I (FgMyoI) occurs close to the binding pocket of the allosteric inhibitor phenamacril and causes severe inhibition on mycelial growth of F. graminearum strain PH-1. Here, based on extensive Gaussian accelerated molecular dynamics simulations and wet experiments, we elucidate the underlying molecular mechanism of the abnormal functioning of the FgMyoIC423D...

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PMID: 38226494
DOI: 10.1021/acs.jafc.3c08648

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