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Article

Unveiling the Mechanism of Phenamacril Resistance in F. graminearum: Computational and Experimental Insights into the C423A Mutation in FgMyoI.

Journal of agricultural and food chemistry - 17 Jul 2024

Bao Yiqiong, Jia Fangying, Lin Yun, Song Guohong, Li Mengrong, Xu Ran, Wang Hancheng, Zhang Feng, Guo Jingjing

Abstract excerpt

Phenamacril (PHA) is a highly selective fungicide for controlling fusarium head blight (FHB) mainly caused by F. graminearum and F. asiaticum. However, the C423A mutation in myosin I of F. graminearum (FgMyoI) leads to natural resistance to PHA. Here, based on the computational approaches and biochemical validation, we elucidate the atomic-level mechanism behind the natural resistance of F. graminearum to the...

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PMID: 38959424
DOI: 10.1021/acs.jafc.4c03467

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