Article
Simplified drug efficacy evaluation system for vasopressin neurodegenerative disease using mouse disease-specific induced pluripotent stem cells.
Peptides - 1 Mar 2024
Miwata Tsutomu, Suga Hidetaka, Mitsumoto Kazuki, Zhang Jun, Hamada Yoshimasa, Sakakibara Mayu, Soen Mika, Ozaki Hajime, Asano Tomoyoshi, Miyata Takashi, Kawaguchi Yohei, Yasuda Yoshinori, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Hagiwara Daisuke, Iwama Shintaro, Oyadomari Seiichi, Arima Hiroshi
Abstract excerpt
Familial neurohypophyseal diabetes insipidus (FNDI) is a degenerative disorder in which vasopressin-secreting neurons degenerate over time due to the production of mutant proteins. We have demonstrated therapeutic effects of chemical chaperones in an FNDI mouse model, but the complexity and length of this evaluation were problematic. In this study, we established disease-specific mouse induced pluripotent stem...
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