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Article

Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis.

World journal of surgical oncology - 11 Jan 2024

Liu Ben, Liu Gang, Liu Binbin, Guo Yao, Peng Ningning, Li Tiejun

Abstract excerpt

OBJECTIVE: We aimed to provide a reference based on evidence for an individualized clinical medication of high-dose methotrexate (HD-MTX) in osteosarcoma patients by evaluating the effect of gene polymorphism on adverse reactions of HD-MTX usage. METHODS: Several databases were combed for research on the association between gene polymorphisms and adverse reactions to HD-MTX up to January 2023. A meta-analysis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38212758
DOI: 10.1186/s12957-023-03287-0
PMCID: PMC10782754

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