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Article

Tuberous sclerosis complex proteins control axon formation.

Genes & development - 15 Sept 2008

Choi Yong-Jin, Di Nardo Alessia, Kramvis Ioannis, Meikle Lynsey, Kwiatkowski David J, Sahin Mustafa, He Xi

Abstract excerpt

Axon formation is fundamental for brain development and function. TSC1 and TSC2 are two genes, mutations in which cause tuberous sclerosis complex (TSC), a disease characterized by tumor predisposition and neurological abnormalities including epilepsy, mental retardation, and autism. Here we show that Tsc1 and Tsc2 have critical functions in mammalian axon formation and growth. Overexpression of Tsc1/Tsc2...

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Source

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Identifiers

PMID: 18794346
DOI: 10.1101/gad.1685008
PMCID: PMC2546692

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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