Article
Fertility preservation in BRCA-mutated women: when and how?
Future oncology (London, England) - 1 Feb 2018
Grynberg Michaël, Raad Jade, Comtet Marjorie, Vinolas Claire, Cédrin-Durnerin Isabelle, Sonigo Charlotte
Abstract excerpt
BRCA 1 and 2 genes play a critical role in the safeguarding of DNA integrity. It is now well established that BRCA1 and BRCA2-mutated women are at increased risk of breast and ovarian cancers. However, several lines of evidence indicate that this genetic status may also be associated with ovarian dysfunction, in particular a reduced ovarian reserve. Considering the gonadal toxicity of cancer treatments and the...
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