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Article

The evolutionary origins of multiple sclerosis.

Revue neurologique - 1 May 2026

Barrie W

Abstract excerpt

There are two main evolutionary theories for why modern humans develop multiple sclerosis (MS). The first, antagonistic pleiotropy, argues that genetic variants that predispose people to MS are protective against infections; this explains why these genetic variants persist at high frequency. The second, the Old Friends hypothesis, argues that reduced exposure to ancient, co-evolved micro-organisms like helminths...

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PMID: 41935913
DOI: 10.1016/j.neurol.2026.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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