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Article

Clinical and molecular genetics of Alagille syndrome.

Current opinion in pediatrics - 1 Dec 1999

Krantz I D, Piccoli D A, Spinner N B

Abstract excerpt

Alagille syndrome (AGS) is a dominantly inherited disorder characterized by bile duct paucity and resultant liver disease in combination with cardiac, skeletal, ocular, and facial abnormalities. Jagged1 (JAG1) has been identified as the AGS disease gene. It encodes a ligand in the Notch signaling pathway that is involved in cell fate determination. AGS is the first developmental disorder to be associated with...

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Source

Identifiers

PMID: 10590916
DOI: 10.1097/00008480-199912000-00015

Genes

JAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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