Theorectical mechanisms for synthesis of carcinogen-induced embryonic proteins: III. The tRNA methylases; methylation mechanism and function.

Abstract excerpt

It is contended that redundant repressed tRed) with carcinogens in adult cells. Supportive evidence, especially from molecular model building, is presented for a mechanism of tRNA methylation. In this mechanism the adenine moiety of S-adenosyl-L-methionine base-pairs with uracil for all tRNA methylations. Furthermore it is proposed that such methylations are required during the transcription of a tRNA molecule in...

Topics

• Animals
• Carcinogens
• Enzyme Induction
• Fetal Proteins
• Fetus
• Liver
• Methylation
• Models, Molecular
• Phenotype
• Phenylalanine
• RNA, Transfer
• Rats