Article
Relapsed/Refractory Peripheral T-Cell Lymphoma-Associated Hemophagocytic Lymphohistiocytosis With UNC13D and CD27 Germline Mutations.
Cell transplantation - 1 Jan 2000
Yang Tingting, Chen Rongrong, Zhang Mingming, Jing Ruirui, Geng Jia, Wei Guoqing, Luo Yi, Xiao Pingnan, Hong Ruimin, Feng Jingjing, Fu Shan, Zhao Houli, Cui Jiazhen, Huang Simao, Huang He, Hu Yongxian
Abstract excerpt
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory disease characterized by familial and acquired forms. Here, we present the case of a 26-year-old male patient with relapsed/refractory peripheral T-cell lymphoma and concurrent HLH. Whole-exon sequencing revealed germline mutations associated with HLH, including those in critical genes such as CD27 and UNC13D and other germline heterozygous...
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