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In vivo measurement of RBC survival in patients with sickle cell disease before or after hematopoietic stem cell transplantation

5 Jan 2024

Abstract excerpt

ABSTRACT: Stable, mixed-donor-recipient chimerism after allogeneic hematopoietic stem cell transplantation (HSCT) for patients with sickle cell disease (SCD) is sufficient for phenotypic disease reversal, and results from differences in donor/recipient-red blood cell (RBC) survival. Understanding variability and predictors of RBC survival among patients with SCD before and after HSCT is critical for gene therapy...

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PMID: 38181784
DOI: 10.1182/bloodadvances.2023011397

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