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Hematopoietic Cell Transplantation for Sickle Cell Disease

5 Jan 2021

Abstract excerpt

Sickle cell disease (SCD) is a severe autosomal recessively inherited disorder of the red blood cell characterized by erythrocyte deformation caused by the polymerization of the abnormal hemoglobin, which leads to erythrocyte deformation and triggers downstream pathological changes. These include abnormal rheology, vaso-occlusion, ischemic tissue damage, and hemolysis-associated endothelial dysfunction. These...

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PMID: 33469520
DOI: 10.3389/fped.2020.551170

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