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Red cell exchange: special focus on sickle cell disease

24 Nov 2014

Abstract excerpt

The primary function of red blood cells (RBCs) is to deliver oxygen from the lungs to tissues. Tissue hypoxia occurs when the oxygen-carrying capacity of RBCs is compromised due primarily to 3 causes: (1) a reduction in circulating RBC mass, (2) an increase in circulating RBC mass, or (3) abnormal hemoglobin (Hb) that either does not sufficiently release oxygen to tissues (high-oxygen-affinity hemoglobin) or...

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PMID: 25696893
DOI: 10.1182/asheducation-2014.1.450

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