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Article

Platelet-derived growth factor subunit-B mediating the effect of dickkopf-1 on acute myocardial infarction risk: a two-step Mendelian randomization study.

Aging - 3 Jan 2024

Li Jun-Shan, Zheng Peng-Fei, Rong Jing-Jing, Zheng Zhao-Fen, Liu Zheng-Yu, Wang Chang-Lu

Abstract excerpt

Previous studies have indicated a potential connection between plasma levels of Dickkopf-1 (DKK1) and platelet-derived growth factor subunit-B (PDGF-B) with the development of atherosclerosis. However, the causal relationship between DKK1, PDGF-B, and the risk of acute myocardial infarction (AMI) is yet to be established. To address this research gap, we conducted Mendelian randomization (MR) and mediation...

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Identifiers

PMID: 38175715
DOI: 10.18632/aging.205413
PMCID: PMC10817415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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