Host genetic regulation of human gut microbial structural variation.

doi:10.1038/s41586-023-06893-w

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Article

Host genetic regulation of human gut microbial structural variation.

Nature - 1 Jan 2024

Zhernakova Daria V, Wang Daoming, Liu Lei, Andreu-Sánchez Sergio, Zhang Yue, Ruiz-Moreno Angel J, Peng Haoran, Plomp Niels, Del Castillo-Izquierdo Ángela, Gacesa Ranko, Lopera-Maya Esteban A, Temba Godfrey S, Kullaya Vesla I, van Leeuwen Sander S, Xavier Ramnik J, de Mast Quirijn, Joosten Leo A B, Riksen Niels P, Rutten Joost H W, Netea Mihai G, Sanna Serena, Wijmenga Cisca, Weersma Rinse K, Zhernakova Alexandra, Harmsen Hermie J M, Fu Jingyuan

Abstract excerpt

Although the impact of host genetics on gut microbial diversity and the abundance of specific taxa is well established1-6, little is known about how host genetics regulates the genetic diversity of gut microorganisms. Here we conducted a meta-analysis of associations between human genetic variation and gut microbial structural variation in 9,015 individuals from four Dutch cohorts. Strikingly, the presence rate...

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PMID: 38172637
DOI: 10.1038/s41586-023-06893-w
PMCID: PMC10808065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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