Article

A simple, cost efficient assay for assessing the functional impact of single and multi-gene variant combinations

2025-07-11

Abstract excerpt

Obesity is a major global health burden driven by both genetic and environmental factors. While monogenic forms are rare, their identification is essential given the availability of targeted therapies. However, genetic testing frequenctly uncovers many variants of unknown significance (VUS), highlighting the need for functional assays to enable precision therapeutic decisions. Here, we describe a simple and cost-e...

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Literature Corpus work: 2394a470-f964-52c2-a192-3b4e80ffd12d
DOI: 10.1101/2025.07.11.663622

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