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Article

NOTCH2 promotes osteoclast maturation and metabolism and modulates the transcriptome profile during osteoclastogenesis.

The Journal of biological chemistry - 1 Feb 2024

Canalis Ernesto, Schilling Lauren, Yu Jungeun, Denker Emily

Abstract excerpt

Notch signaling plays a key regulatory role in bone remodeling and NOTCH2 enhances osteoclastogenesis, an effect that is mostly mediated by its target gene Hes1. In the present study, we explored mechanisms responsible for the enhanced osteoclastogenesis in bone marrow-derived macrophages (BMM) from Notch2tm1.1Ecan, harboring a NOTCH2 gain-of-function mutation, and control mice. Notch2tm1.1Ecan mice are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor Activator of Nuclear Factor-kappa B

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Source

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Identifiers

PMID: 38159855
DOI: 10.1016/j.jbc.2023.105613
PMCID: PMC10837628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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