Article
Assessing the association between global structural brain age and polygenic risk for schizophrenia in early adulthood: A recall-by-genotype study.
Cortex; a journal devoted to the study of the nervous system and behavior - 1 Mar 2024
Constantinides Constantinos, Baltramonaityte Vilte, Caramaschi Doretta, Han Laura K M, Lancaster Thomas M, Zammit Stanley, Freeman Tom P, Walton Esther
Abstract excerpt
Neuroimaging studies consistently show advanced brain age in schizophrenia, suggesting that brain structure is often 'older' than expected at a given chronological age. Whether advanced brain age is linked to genetic liability for schizophrenia remains unclear. In this pre-registered secondary data analysis, we utilised a recall-by-genotype approach applied to a population-based subsample from the Avon...
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