Article
HPV16 Intratypic Variants in Head and Neck Cancers: A North American Perspective.
Viruses - 12 Dec 2023
Gameiro Steven F, Salnikov Mikhail Y, Zeng Peter Y F, Barrett John W, Nichols Anthony C, Mymryk Joe S
Abstract excerpt
Human papillomavirus (HPV) is the major causative agent for cervical and many head and neck cancers (HNCs). HPVs randomly acquire single nucleotide polymorphisms (SNPs) that may become established via positive selection. Within an HPV type, viral isolates differing by <2% in the L1 region are termed "variants" and classified based on combinations of SNPs. Studies in cervical cancer demonstrate clear differences...
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