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Article

The Discovery of Indole-2-carboxylic Acid Derivatives as Novel HIV-1 Integrase Strand Transfer Inhibitors.

Molecules (Basel, Switzerland) - 8 Dec 2023

Wang Yu-Chan, Zhang Wen-Li, Zhang Rong-Hong, Liu Chun-Hua, Zhao Yong-Long, Yan Guo-Yi, Liao Shang-Gao, Li Yong-Jun, Zhou Meng

Abstract excerpt

As an important antiviral target, HIV-1 integrase plays a key role in the viral life cycle, and five integrase strand transfer inhibitors (INSTIs) have been approved for the treatment of HIV-1 infections so far. However, similar to other clinically used antiviral drugs, resistance-causing mutations have appeared, which have impaired the efficacy of INSTIs. In the current study, to identify novel integrase...

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Identifiers

PMID: 38138510
DOI: 10.3390/molecules28248020
PMCID: PMC10745497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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