Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alpha-1-Antitrypsin (A1AT) Proteotyping by LC-MS/MS.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2024

Kemp Jennifer, Ladwig Paula M, Snyder Melissa R

Abstract excerpt

The diagnosis of alpha-1-antitrypsin (A1AT) deficiency is established by quantitation of protein concentration in serum (immunoassay) followed by determination of specific allelic variants by phenotyping (isoelectric focusing (IEF) gel electrophoresis) and/or allele-specific genotyping. Various phenotyping and genotyping methodologies are available, and each has their own advantages and disadvantages. As an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Chromatography, Liquid
Share to Proteomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Tandem Mass Spectrometry

Source

Identifiers

PMID: 38108970
DOI: 10.1007/978-1-0716-3605-3_9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alpha-1-Antitrypsin (A1AT) Proteotyping by LC-MS/MS.PMID 38108970Read ↗

Simultaneous phenotyping and quantification of α-1-antitrypsin by liquid chromatography-tandem mass spectrometry.Semantic proximity Read ↗

Liquid Chromatography-Tandem Mass Spectrometry-Based α1-Antitrypsin (AAT) Testing.Semantic proximity Read ↗

Quantitation of circulating wild-type alpha-1-antitrypsin in heterozygous carriers of the S and Z deficiency alleles.Semantic proximity Read ↗

Can Proteomics Play a Significant Role in the Identification of Biomarkers for Alpha1-Antitrypsin Deficiency?Semantic proximity Read ↗

State-of-the-art testing for alpha-1 antitrypsin deficiency.Semantic proximity Read ↗

Molecular diagnosis of alpha1-antitrypsin deficiency: A new method based on Luminex technology.Semantic proximity Read ↗

A Library of Rare α1-Antitrypsin (AAT) Variant Phenotypes to Aid in the Diagnosis of AAT Deficiency.Semantic proximity Read ↗

Normal Alpha-1-Antitrypsin Variants Display in Serum Allele-Specific Protein Levels.Semantic proximity Read ↗

Evaluation of an integrative diagnostic algorithm for the identification of people at risk for alpha1-antitrypsin deficiency.Semantic proximity Read ↗

Detection of genetic variants of alpha 1-antitrypsin with site-specific monoclonal antibodies.Semantic proximity Read ↗

Reference and interpretive ranges for α(1)-antitrypsin quantitation by phenotype in adult and pediatric populations.Semantic proximity Read ↗

α1-Antitrypsin phenotypes and associated serum protein concentrations in a large clinical population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.