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Article

Liquid Chromatography-Tandem Mass Spectrometry-Based α1-Antitrypsin (AAT) Testing.

American journal of clinical pathology - 15 Mar 2021

Murray Josiah D, Willrich Maria A, Krowka Michael J, Bobr Aleh, Murray David L, Halling Kevin C, Graham Rondell P, Snyder Melissa R

Abstract excerpt

OBJECTIVES: Failure to produce sufficient quantities of functional α1-antitrypsin (AAT) can result in AAT deficiency (AATD) and significant comorbidities. Laboratory testing plays a vital role in AATD, with diagnosis requiring documentation of both a low AAT level and a mutated allele. This retrospective evaluation examines the efficacy of a liquid chromatography-tandem mass spectrometry (LC-MS/MS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33083828
DOI: 10.1093/ajcp/aqaa149

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