Article
α1-Antitrypsin phenotypes and associated serum protein concentrations in a large clinical population.
Chest - 1 Apr 2013
Bornhorst Joshua A, Greene Dina N, Ashwood Edward R, Grenache David G
Abstract excerpt
BACKGROUND: α1-Antitrypsin (AAT) deficiency variants reduce the concentration of serum AAT protease inhibitor and can lead to the development of pulmonary and hepatic disease. Relative frequencies of rare AAT variant phenotypes (non-M, Z, and S) and associated serum concentrations in the clinical population have not been thoroughly described. METHODS: Protein phenotypes were determined by isoelectric focusing...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Algorithms
- Biomarkers
- Child
- Child, Preschool
- Female
- Humans
- Infant
- Isoelectric Focusing
- Male
- Middle Aged
- Phenotype
- Retrospective Studies
- Sensitivity and Specificity
- Young Adult