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Cytolethal distending toxin B inoculation leads to distinct gut microtypes and IBS-D-like microRNA-mediated gene expression changes in a rodent model

18 Dec 2023

Abstract excerpt

Diarrhea-predominant irritable bowel syndrome (IBS-D), associated with increased intestinal permeability, inflammation, and small intestinal bacterial overgrowth, can be triggered by acute gastroenteritis. Cytolethal distending toxin B (CdtB) is produced by gastroenteritis-causing pathogens and may underlie IBS-D development, through molecular mimicry with vinculin. Here, we examine the effects of exposure to...

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PMID: 38108386
DOI: 10.1080/19490976.2023.2293170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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